2020年广西大学“百人计划”周磊教授课题组考研调剂信..

招生人数:8

课题组长简介

周磊，男，39岁，广西大学动物科学技术学院教授、博士生导师，副院长。入选首批广西壮族自治区高层次人才、广西优秀专家、广西“百人计划”，获广西青年五四奖章，中国畜牧兽医学会动物遗传育种学分会理事、生理生化学分会理事，农业生物化学与分子生物学分会理事，亚热带农业生物资源保护与利用国家重点实验室固定研究人员。先后留学德国糖尿病研究中心（杜塞尔多夫）、法国原子能委员会（巴黎）、美国宾夕法尼亚大学（费城）。2013年作为学术带头人引进到广西大学，建立分子营养课题组。广西大学是双一流学科建设高校，入选教育部部区合建高校。课题组隶属国家重点实验室和自治区一流建设学科，课题组现有动物代谢笼、核磁、CT等大型设备，具有生物化学和分子生物学研究的常规设备，在今后几年的双一流建设中还将购置近千万的设备，实验平台不弱于国内、抑或国外相关专业。课题组正在开展基因功能、高通量测序分析、小分子化合物筛选和设计（已购置Discovery Studio软件）等工作，目前已积累非常丰富的组学数据，非常欢迎对生物、生物信息、分子模拟、化学生物学感兴趣的同学加入。联系方式：zhoulei@gxu.edu.cn。

研究方向

营养组学研究（功能基因组、表观基因组、蛋白质组、蛋白质修饰组）

营养小分子的筛选、设计和功能研究

动物重要经济性状的遗传改良

动物生理代谢调控

功能基因的转录调控和信号转导

社会兼职

中国畜牧兽医学会动物遗传育种学分会理事

中国畜牧兽医学会动物生理生化学分会理事

农业生物化学与分子生物学分会理事

广西实验动物学会常务理事

硕士生要求

1. 生物、基础医学、计算化学等相关专业

2. 对生命科学研究、对大数据分析有浓厚兴趣

3. 做事认真踏实，责任心强，有良好的与人相处和沟通的能力及团队合作精神

4. 具备良好的英语读写能力

相关待遇

硕士生除享有国家和课题组固定津贴，根据科研绩效还享有课题组额外奖励，优秀的同学可申请硕博连读。

课题组情况

分子营养课题组依托广西大学动物科学技术学院和亚热带农业生物资源保护与利用国家重点实验室，研究方向为糖脂代谢调控，在医学上主要针对肥胖、糖尿病、脂肪肝等代谢疾病；在畜牧上研究脂肪性状对繁殖、肉质、瘦肉率的调控。已在hepatology、nucleic acids research等高水平杂志上发表多篇论文。课题组长周老师入选广西自治区优秀专家、百人计划、广西大学杰出人才培养计划，团队承担多项国家级、省部级研究课题。

1. 周老师从科研思路、实验技能和论文写作方面亲自指导学生，与学生一起做研究，全方位培养学生

2. 课题组与美国、德国等多个课题组保持着长期合作关系，优秀研究生和博士后根据项目进展和合作需要，有机会赴德国或美国进行联合培养或合作研究，毕业或出站后尽力推荐去国外一流课题组继续深造

3. 博士后和研究生每年至少参加一次国内学术会议

4. 课题组工作氛围轻松友善，为团队成员提供实现自身价值的机会及发展空间

5. 先进的课题组运行模式，每个成员都有独立项目

6. 较为充足的研究经费（详见主持项目）

7. 充足的实验空间和优良的实验设备，具有课题组专用的细胞培养室和动物房

主持项目

1. 广西科技基地和人才专项，2018/12-2021/11。

2. 国家重点研发计划，2018/06-2020/12。

3. 广西大学高层次专业技术人才培养工程“杰出人才培养计划”，2015/08-2021/07。

4. 国家自然科学基金，2014/01-2016/12；2017/01-2020/12。

5. 广西高校引进海外高层次人才“百人计划”，2014年。

6. 广西自然科学基金重点项目，2014/06-2017/05；2020/01-2023/12。

7. 广西大学科研基金（引进人才项目），2013/07-2018/06。

8. 欧洲糖尿病研究基金项目（efsd，欧洲基金会资助），2012/01-2013/06。

9. 教育部博士点新教师基金，2011/01-2013/12。

10. tanita健康体重基金（日本基金会资助），2009/10-2010/10。

11. 欧洲糖尿病研究基金项目（efsd，欧洲基金会资助），2006/10-2007/03。

近年代表作

第一/通讯作者（*）

1. Lei Zhou*, Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Juergen Eckel, Zaiqing Yang*. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 2013, 57: 1384-1393. IF：14.971

2. Lei Zhou, Gwenaelle Le Roux, Cecile Ducrot, Stephane Chedin, Jean Labarre, Michel Riva, Christophe Carles*. Repression of class I transcription by cadmium is mediated by the Protein Phosphatase 2A. Nucleic Acids Res. 2013, 41: 6087–6097. IF：11.147

3. Yixing Li, Kejing Wu, Weili Quan, Lin Yu, Shuang Chen, Chao Cheng, Qijia Wu, Shuhong Zhao, Yi Zhang*, Lei Zhou*. The dynamics of FTO binding and demethylation from the m6A motifs. RNA Biology. 2019, 16: 1179–1189. IF：5.477

4. Zupeng Luo, Zhiwang Zhang, Lina Tai, Lifang Zhang, Zheng Sun, Lei Zhou*. Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers. Epigenomics. 2019, 11(11): 1267-1282. IF: 4.404

5. Zhanyang Tang, Yi Zhou, Jun Xiao, Huan Zhong, Weiwei Miao, Zhongbao Guo, Xu Zhang, Lei Zhou*, Yongju Luo*. Transcriptome Analysis of Ovary Development in Nile Tilapia Under Different Photoperiod Regimes. Frontiers in Genetics. 2019, 10: 894. IF: 3.517

6. Lifang Zhang, Yilin Qi, Zhier ALuo, Siqi Liu, Zhiwang Zhang and Lei Zhou*. Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food & Function. 2019, 10: 216-223. IF：3.241

7. Qiang Li, Yixing Li, Zhiwang Zhang, Huifang Kang, Lifang Zhang, Yuxiang Zhang, Lei Zhou*. SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level. Mol Cell Endocrinol. 2019, 488: 70-78. IF：3.693

8. Li Y, Luo Z, Wu X, Zhu J, Yu K, Jin Y, Zhang Z, Zhao S, Zhou L*. Proteomic Analyses of Cysteine Redox in High-Fat-Fed and Fasted Mouse Livers: Implications for Liver Metabolic Homeostasis. J Proteome Res. 2018, 17(1): 129-140. IF：3.78

9. Kang Huifang, Zhang Zhiwang, Yu Lin, Li Yixing*, Liang Mingzhen, Zhou Lei*. FTO reduces mitochondria and promotes hepatic fat accumulationthrough RNA demethylation. Journal of Cellular Biochemistry. 2018, 119(7): 5676-5685. IF：3.448

10. Yixing Li, Huifang Kang, Yi Chu, Yi Jin, Lifang Zhang, Ranran Yang, Zhiwang Zhang, Shuhong Zhao, Lei Zhou*. Cidec differentially regulates lipid deposition and secretion through two tissue-specific isoforms. Gene. 2018, 641C: 265-271. IF：2.415

11. Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li*, Lei Zhou*. Comparative analyses of long non-coding RNA in lean and obese pig. Oncotarget. 2017, 8(25): 41440-41450. IF：5.168

12. Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou*. Association between serum resistin concentration and hypertension: A systematic review and meta-analysis. Oncotarget. 2017, 8(25): 41529-41537. IF：5.168

13. Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou*. Transcriptomic analysis of Bama pig's liver in various nutritional status reveals a metabolic difference of fatty acid. Food & Function. 2017, 8: 3480-3490. Cover Paper, IF：3.241

14. Qiang Li, Yuxi Cai, Jing Huang, Xiaolan Yu, Jun Sun, Zaiqing Yang*, Zhou L*. Resistin impairs glucose permeability in EA.hy926 cells by downregulating GLUT1 expression. Mol Cell Endocrinol. 2016, 434: 127-34. IF：3.693

15. Jiang Y, Lu L, Hu Y, Li Q, An C, Yu X, Shu L, Chen A, Niu C, Zhou L*, Yang Z*. Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway. Sci Rep. 2016, 6: 22193. IF：4.259

16. Y Li, L Zhou*, Vitamin D Deficiency, Obesity and Diabetes. Cell Mol Biol. 2015, 61(3): 35-38. IF：0.92

17. Li H, Chen A, Shu L, Yu X, Gan L, Zhou L*, Yang Z*. Translocation of CIDEC in hepatocytes depends on fatty acids. Genes Cells. 2014, 19(11): 793-802. IF：1.993

18. Lei Zhou, Lijie Zhang, Qingjie Meng, Congcong Niu, Dan Jin, An Yu, Li gan, Zaiqing Yang. C/EBP? promotes transcription of the porcine perilipin5 gene. Mol Cell Endocrinnol. 2012, 364:28-35. IF：3.693

19. Lei Zhou, Qingjie Meng, Tao Qian, Zaiqing Yang. Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. J Nat Med. 2011, 65(1): 50-6. IF：1.982

20. Lei Zhou, Henrike Sell, Kristin Eckardt, Zaiqing Yang, Jürgen Eckel. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS letters. 2007, 581: 4303-4308. IF：3.623

21. Lei Zhou, Yixing Li, Tao Nie, Shengqiu Feng, Huaping Chen, Zaiqing Yang. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J BIOCHEM MOL BIOL. 2007, 40(4): 525-31. IF：2.021

22. Lei Zhou, Yixing Li, Tao Xia, Shengqiu Feng, Xiaodong Chen, Zaiqing Yang. Resistin Overexpression Impaired Glucose Tolerance in Hepatocytes. Eur Cytokine Netw. 2006, 17(3): 189-95. IF：2.364

23. Lei Zhou, Tao Xia, Yixing Li, Xiaodong Chen, Yin Peng, Zaiqing Yang. Transcriptional Regulation of the Resistin Gene. Domest Anim Endocrinol. 2006, 30(2): 98-107. IF：1.644

合作论文

24. Chen Ao, Chen Xiaodong, Cheng Shiqiang, Shu Le, Yan Meiping, Yao Lun, Wang Binyu, Huang Shuguang, Zhou Lei, Yang Zaiqing, Liu Guoquan. FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids. 2018, 1863(5): 538-548. IF：5.547

25. Yanling Wu, Qinqiang Long, Bin Feng, Xiaoyue Zhu, Zifeng Zheng, Sumin Gao, Mingju Gao, Li Gan, Lei Zhou, Zaiqing Yang. Molecular cloning and characterization of the anti-obesity gene adipose in pig. Gene. 2012, 509: 110-9. IF：2.415

26. Chen Z, Gao X, Lei T, Chen X, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z. Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011, 33(7): 1327-37. IF：1.73

27. Zhang J, Lei T, Chen X, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z. Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation. 2010, 33(1): 25-33. IF：2.955

28. Qi YM, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Mol Biol Rep. 2009, 36(7): 1881-8. IF：1.828

29. Y. H. Li, T. Lei, X. D. Chen, T. Xia, Q. Q. Long, J. Zhang, S. Q. Feng, Y. Peng, L. Zhou, Z. Q. Yang. Molecular cloning, chromosomeal location and expression pattern of porcine CIDEa and CIDEc. Mol Biol Rep. 2009, 36(3): 575-82. IF：1.828

30. Qi M, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, Characterization, Chromosomal Mapping and Tissue Transcription Analysis of Porcine CREB2 and CREB3 Genes. Folia Biol. 2009, 55(4): 137-44. IF：0.939

31. Huaping Chen, Wenshu Yao, Dan Jin, Tao Xia, Xiaodong Chen, Ting Lei, Lei Zhou, Zaiqing Yang. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochem Genet. 2008, 46(7-8): 398-405. IF：1.543

32. Y Li, L Zhou, Y Li, D Chen, X Tan, L Lei and J Zhou. A Nodule-Specific Plant Cysteine Proteinase, AsNODF32, Is Involved in Nodule Senescence and Nitrogen Fixation Activity of the Green Manure Legume Astragalus sinicus. New Phytologist. 2008, 180: 185-192. IF：7.33

33. Huaping Chen, Tao Xia, Lei Zhou, Xiaodong Chen, Li Gan, Wenshu Yao, Yin Peng, and Zaiqing Yang. Gene organization, alternate splicing and expression pattern of porcine visfatin gene. Domest Anim Endocrinol. 2007; 32: 235-45. IF：1.644

34. HW Yang, T Xia, ZL Chen, SQ Feng, Y Peng, L Zhou, L Gan, and ZQ Yang. Cloning, chromosomal localization and expression patterns of porcine Kruppel-like factors 4, -5, -7 and the early growth response factor 2. Biotechnol Lett. 2007; 29(1): 157-63. IF：1.73

35. Feng SQ, Chen XD, Xia T, Gan L, Qiu H, Dai MH, Zhou L, Peng Y, Yang ZQ. Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4. Cytogenet Genome Res. 2006; 114(1): 44-9. IF：1.354

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