四川大学生命科学学院导师：王亚军 正文

　　
　　姓名：王亚军　性别：男
　　职称：教授　学院：生命科学学院
　　联系方式：
　　办公室电话：028-85415025
　　电子邮件：cdwyjhk@gmail.com
　　
　　学习与工作简历：
　　1987-1991: 西南师范大学生物系，理学学士。
　　1991-1994: 四川大学生物系，理学硕士。
　　1994-1999: 四川大学生物系 助教、讲师。
　　1999-2003: 香港中文大学(The Chinese University of Hong Kong) 博士。
　　2003-2004: 香港中文大学（The Chinese University of Hong Kong）博士后。
　　2004-2007: 香港大学 (The University of Hong Kong), 博士后。
　　2007-现在： 四川大学生命科学学院 。

　　个人研究简介：
　　斑马鱼作为模式生物一直在发育生物学、比较内分泌学等领域扮演重要角色。王亚军博士在香港中文大学博士攻读期间（1999-2003），以斑马鱼为研究模型，探究卵巢产生的一些生长因子，包括激活素（Activins）及其结合蛋白(Follistatin)，表皮生长因子（EGF）及其受体（EGFR），以及PACAP及其受体在控制卵泡发育与类固醇激素生成中的作用。 二零零四年，王亚军博士加入香港大学理学院长梁志清教授实验室从事博士后研究。以家鸡为研究模型，围绕神经内分泌生长轴（调节生长发育的主要途径）,致力于基因功能鉴定以及基因网络调控解析，并首次在家鸡等非哺乳类脊椎动物中鉴定到生长激素释放激素 (GHRH)及其两个专一性受体(GHRHR1 , GHRHR2)基因。 王亚军博士的系列研究结果已先后发表在<Endocrinology>, <Biology of Reproduction>, <PNAS>等领域内著名刊物上。 回到四川大学后，王亚军博士在四川大学引进人才基金支持下，组建畜禽功能基因研究平台，主以家鸡、斑马鱼为模型探究： 1) 神经多肽 (如:GHRH, PrRP, GCG2等)、神经递质、生长因子等对垂体功能的调节及其胞内信号传导机制；2) 基因功能及其表达调控; 3) 经济动物重要性状形成分子基础；4) 动物生长与代谢调节机制。
　　
　　研究方向：
　　动物细胞生物学、繁殖生物学、比较内分泌学
　　
　　项目支持：
　　国家自然科学基金、转基因生物新品种培育重大专项、国家高技术研究发展计划.

　　代表性论文：
　　1. Wang Y*, Wang CY, Wu Y, et al. Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology, 153: p1-14, 2012 (online) (*通讯作者) (IF=4.993).
　　
　　2. Wang Y*, Huang G, Li J., et al., Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280, 2012 (*通迅作者) (IF=4.118).
　　
　　3. Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y* Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology (online), p1-15, 2012 (* 通迅作者) (IF= 1.896)
　　
　　4. Ho JC, Kwok AH, Zhao D, Wang Y*, et al. Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, 2011 (*通讯作者) (IF=3.108).
　　
　　5. Ruiqiang Li, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang*… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang. The sequence and de novo assembly of the giant panda genome. Nature, 463: 311-317, 2010 (IF=36.101)
　　
　　6. Wang Y*, Li J, Kwok AHY, et al., A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative endocrinology 166: 200-210, 2010. (IF=3.108)
　　
　　7. Wang Y*, Li J, C. Wang CY, et al., Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31, 2010 (IF=1.896).
　　
　　8. Lynch VJ，Tanzer A, Wang Y*, et al., Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105: 14925-14933, 2008. (IF=9.598)
9. Wang J, Wang Y*, Li X, et al., Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688, 2008 (IF=1.603)
　　
　　10. Kwok AHY, Wang Y*, Wang CY, et al., Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4) General and Comparative Endocrinology, 157: 99-106, 2008 (IF=3.108)
11. Wang Y*, Li J, Wang CY, et al., Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416, 2007. (IF=5.045)
　　
　　12. Wang Y*, Li J，Wang CY, et al., Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440, 2007 (IF=5.045).
　　
　　13. Wang Y, Wang Z, Li J, Wang Y*, et al., A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, 2007 (IF=3.368).
　　
　　14. Kwok AHY, Wang Y*, Wang CY, et al., Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430, 2007 (IF=1.603).
15. Wang CY*, Wang Y*, Kwok AHY et al., Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536, 2007 (IF=2.636) (同等贡献).
　　
　　16. Wang CY, Wang Y*, Li J et al. Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science, 85: 569-576, 2006, (IF=1.603).
　　
　　17. Kwok HF, So WK, Wang Y* et al, Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction, 72: 1370-1381, 2005 (IF=3.670).
18. Wang Y* & Ge W Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction, 71: 749-760, 2004 (IF=3.670).
　　
　　19. Wang Y* & Ge W. Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction, 71: 2056-2064, 2004 (IF=3.670).
20. Wang Y* & Ge W. Cloning of zebrafish ovarian P450c17 (CYP17,17α-hydroxylase/17,20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology, 135: 241-249, 2004 (IF=3.108)
　　
　　21. Wang Y* & Ge W Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology, 144: 491-499, 2003 (IF=5.045).
　　
　　22. Wang Y*, Wong AOL & Ge W Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology, 144: 4799-4810, 2003 (IF=5.045).
　　
　　23. Wang Y* & Ge W Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction, 69: 1998-2006, 2003. (IF=3.670)
　　
　　24. Wang Y* & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology, 134: 308-315 (IF=3.108)
　　
　　25. Wang Y* & Ge W. Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology, 127: 209-216, 2002 (IF=3.108).
　　
　　会议报告
　　1) 王亚军 The 10th International Symposium on Avian Endocrinology 2012 (ISAE2012) (June 5-9, 2012, Japan).（大会报告, Invited speaker）Title: ‘Molecular characterization of the receptors for chicken GHRH, PrRP and their related peptides: An emerging evolutionary story’
获奖:
　　2003年度 “香港中文大学研究生最佳研究成绩奖”
　　
　　
　　 

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