姓　　名： 袁若 性别： 男

出生年月： 1963-8-0 工作单位： 西南大学

所在院系： 化学化工学院 职称： 教授

行政职务： 招生专业： 070302分析化学

研究领域： 分析化学 是否兼职： 否

指导博士生总数： 指导硕士生总数：

目前博士生数： 目前硕士生数：

个人简介

1984年获湖南大学化学化工学院分析化学专业学士学位，1991年获湖南大学化学化工学院分析化学专业硕士学位，1994年获湖南大学化学化工学院分析化学专业博士学位。1994年分配在湖南大学分析测试中心工作，主要从事生物和化学传感器的研究，1994年7月~1994年12月在香港浸会大学化学系做访问学者，从事基于主客体效应的有机分子传感器研究。1995年1月~1996年3月在日本大阪大学工学部应用化学系米山宏（H.Yoneyama）教授实验室做博士后从事酶催化电化学氧化还原及纳米材料传感器研究。1998年8月~1999年8月在香港城市大学化学及生物系作高级研究员，从事电化学传感器及DNA芯片研制工作。1999年调到西南大学化学化工学院工作。2001获重庆市十大青年五四奖章，2002年入选为重庆市首届学术技术带头人后备人选， 2002年获教育部优秀青年教师资助计划资助，2004年获得国务院政府津贴。2005年荣获重庆市高校中青年骨干教师称号。 　　袁若及其研究小组对生物及化学传感器进行了系统的研究，并取得了显著的成果，其研究水平达到国际先进水平。在免疫生物传感器研究方面，他结合纳米技术、反电荷技术、溶胶-凝胶技术研制出了白喉、乙肝、风疹、脑膜炎等传染性疾病及甲胎蛋白、癌胚抗原肿瘤标志物生物传感器并用于临床试验。在酶生物传感器研究方面，他采用生物膜技术、自组装技术进行生物电化学直接催化研制出葡萄糖氧化酶、过氧化氢酶、醇脱氢酶等生物酶传感器。在DNA生物传感器研究方面，他采用交流阻抗技术、电容技术及芯片技术研究出了HIV基因片段检测传感器及地中海贫血、白血病等生物芯片。在生物催化合成研究方面，他采用金属配合物、辅酶及电子媒体存在下借助生物酶催化电化学合成十余种对称、非对称羰基化合物、α-羟基氨基酸；建立起单酶催化手性羰基化合物的非对称合成新体系，所得对映体过剩率（ee%）可达99-100%。在电化学传感器研究方面，他定向设计合成了30余种新型手性、非手性Schiff碱金属配合物及冠醚、杯环芳烃，采用主—客体分子识别技术及离子—载体特殊作用，研制出了20余种新型无机离子、有机分子化学传感器。研制出的新型生物及化学传感器已用于工业过程控制、临床医学及制药工业。袁若及其研究小组研究的新型高分子膜pH电极，克服了目前玻璃膜pH 电极存在的高阻抗、易破碎、不耐HF腐蚀等缺陷，其研究成果已达到国际领先水平。该高分子膜pH传感器产品于2003年被列为国家重点新产品计划，并获国家科技部科技型中小企业技术创新基金资助。2003年，他成立了一家重庆亚通化工有限公司，该公司已被列为重庆市高科技企业，其pH传感器产品已走向市场受到用户好评，并获得较好的经济和社会效益。

著作及论文

在国内外重要期刊上如《Anal. Chem.》、《J. Org. Chem.》、《Langmuir》、《Biosens. Bioelectron.》、《Electrochem. Commun.》、《Anal. Chim. Acta》、《Anal. Bioanal. Chem.》、《Electroanalysis》、《中国科学（B辑）》、《科学通报》《化学学报》等发表120余篇学术论文，其中80篇论文被SCI收录。在《SCI》收录中被他人引用315次，其中有三篇论文在《SCI》收录中被他人引用次数超过30次。申请国家发明专利2项。 　　1. D. P. Tang, R. Yuan*, Y. Q. Chai, “Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultaneous Multiple 1. D. P. Tang, R. Yuan*, Y. Q. Chai, “Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultaneous Multiple Immunoassays,” Clinical Chemistry,2007, 53(7), 1323–1329. 　　2. D. P. Tang, R. Yuan*, Y. Q. Chai, et al, “Core/shell magnetic CoFe2O4/SiO2 porous composite nanoparticles as immobilized affinity supports for clinial immunoassays”, Advanced Functional  Material, 2007, 17(6): 976-982. 　　3. Y. Zhuo, R. Yuan*, Y. Q. Chai, A. L. Sun, Y. Zhang，J. Z. Yang, “A tris(2,2\'-bipyridyl)cobalt(III)-bovine serum albumin composite membrane for biosensors”, Biomaterials, 2006, 27, 5420-5429. 　　4. D. P. Tang, R. Yuan*, Y. Q. Chai, “Magnetic core-shell Fe3O4@Ag nanoparticle-coated carbon paste interface for studies of carcinoembryonic antigen in clinical immunoassay”, Journal of Physical Chemistry B, 2006, 110, 11640-11646. 　　5. N. Li, R. Yuan*, Y. Q. Chai, S. H. Chen, H. Z. An, W. J. Li, “ New Antibody Immobilization Strategy Based on Gold Nanoparticles and Azure I/Multi-Walled Carbon Nanotubes Composite Membrane for Amperometric Enzyme Immunosensor”, Journal of Physical Chemistry C,2007, 111, 8443-8450. 　　6. R. Yuan*, D. P. Tang, Y. Q. Chai, X. Zhong, Y. Liu, J. Y. Dai, “Ultrasensitive Potentiometric Immunosensor Based on SA and OCA Techniques for Immobilization of HBsAb with Colloidal Au and Polyvinyl Butyral as Matrixes”, Langmuir, 2004, 20(17), 7240 – 7245. 　　7. S. H. Chen, R. Yuan*, Y. Q. Chai, L. Y. Zhang, N. Wang, X. L. Li, “Amperometric third-generation hydrogen peroxide biosensor based on the immobilization of hemoglobin on multiwall carbon nanotubes and gold colloidal nanoparticles”, Biosensors and Bioelectronics, 2007, 22, 1268-1274. 　　8. D. P. Tang, R. Yuan*, Y. Q. Chai, “Biochemical and immunochemical characterization of the antigen-antibody reaction on a non-toxic biomimetic interface immobilized red blood cells of crucian carp and gold nanoparticles”, Biosensors and Bioelectronics, 2007, 22, 1116-1120. 　　9. D. P. Tang, R. Yuan*, Y. Q. Chai, Y. Z. Fu, J. Y. Dai, Y. Liu, X. Zhong, “New amperometric and potentiometric immunosensors based on gold noparticles/tris(2,2’-bipyridy) cobalt(III) multilayer films for hepatitis B surface antigen determinations”, Biosensors and Bioelectronics, 2005, 21(4), 539-548. 　　10. D. P. Tang, R. Yuan*, Y. Q. Chai, Y. Z. Fu, “Study on electrochemical behavior of a diphtheria immunosensor based on silica/silver/gold nanoparticles and polyvinyl butyral as matrices”, Electrochemistry Communications, 2005, 7(2), 177-182. 　　11. Y. Zhuo, R. Yuan*, Y. Q. Chai, D. P. Tang, L. Y. Zhang, N. Wang, X. L. Li, Q. Zhu,“A reagentless amperometric immunosensor based on gold nanoparticles/ thionine /Nafion-membrane-modified gold electrode for determination of α-1-fetoprotein”, Electrochemistry Communications, 2005, 7(4), 355-360. 　　12. L. Y. Zhang, R. Yuan*, X. Q. Huang, Y. Q. Chai, S. R. Cao, “Potentiometric immunosensor based on antiserum of Japanese B encephalitis immobilized in nano-Au/polymerized o-phenylenediamine film”, Electrochemistry Communications, 2004, 6(12),  1222-1226. 　　13. R. Yuan*, L. Y. Zhang, Q. F. Li, Y. Q. Chai, S. R. Cao,“A label-free amperometric immunosenor based on the multi-layer structure of prussian blue / polymerized o-phenylenediamine / nano-Au /polymerized o-phenylenediamine / nano-Au / antibody for the determination of Japanese B encephalitis vaccine”, Analytica Chimica Acta, 2005, 531(1), 1-5. 　　14. Y. Zhuo, R. Yuan* , Y. Q. Chai, Y. Zhang, X. L. Li, Q. Zhu, N. Wang, “An amperometric immunosensor based on immobilization of hepatitis B surface antibody on gold electrode modified gold nanoparticles and horseradish peroxidase”, Analytica Chimica Acta, 2005, 548, 205-210. 　　15. D. P. Tang, R. Yuan*, Y. Q. Chai, “Electrochemical immuno-bioanalysis for carcinoma antigen 125 based on thionine and gold nanoparticles-modified carbon paste interface ”, Analytica Chimica Acta, 2006,  564(2), 158-165. 　　16. L. Y. Zhang, R. Yuan, Y. Q. Chai, X. L. Li, “Investigation of the electrochemical and electrocatalytic behavior of positively charged gold nanoparticle and l-cysteine film on an Au electrode”, Analytica Chimica Acta, 2007, 59 (1),  99-105. 　　17. Z. Q Tong, R. Yuan, Y. Q. Chai, Y. Xie, S. H. Chen, “A novel and simple biomolecules immobilization method: Electro-deposition ZrO2 doped with HRP for fabrication of hydrogen peroxide biosensor”, Journal of Biotechnology, 2007, 128, 567-575. 　　18. Y. T. Shi, R. Yuan*, Y.Q. Chai, M.Y. Tang, X. L. He, “Amplification of antigen–antibody interactions via back-filling of HRP on the layer-by-layer self-assembling of thionine and gold nanoparticles films on Titania nanoparticles/gold nanoparticles-coated Au electrode”, Journal of Electroanalytical Chemistry, 2007, 604, 9–16 　　19. Y. R. Yuan, R. Yuan*, Y. Q. Chai, Y. Zhuo, Y. T Shi, X. L. He, X. M. Miao, “A Reagentless Amperometric Immunosensor for Alpha-Fetoprotein Based on Gold Nanoparticles/TiO2 Colloids/Prussian Blue Modified Platinum Electrode”, Electroanalysis ,2007,19(13), 1402 – 1410. 　　20. F. C. Wang, R. Yuan, Y. Q. Chai, D. P. Tang, “Probing traces of hydrogen peroxide by use of a biosensor based on mediator-free DNA and horseradish peroxidase immobilized on silver nanoparticles”,Analytical Bioanalytical Chemistry, 2007, 387(2), 709-717. 　　21. Y. T. Shi, R. Yuan*, Y. Q. Chai, X. L. He, “Development of an amperometric immunosensor based on TiO2 Nanoparticles and gold Nanoparticles” , Electrochimica Acta, 2007, 52, 3518-3524. 　　22. H. Z. An, R. Yuan*, Y. Q. Chai, D. P. Tang, N. Li, “Dual-Amplification of Antigen-Antibody Interactions via Back-Filling Gold Nanoparticles on (3-Mercaptopropyl) Trimethoxysilane Sol-Gel Functionalized Interface” , Electroanalysis, 2007, 19(4), 479-486. 　　23. F. X. Gao, R. Yuan*, Y. Q. Chai, M. Y. Tang, S. R. Cao, S. H. Chen, “Amperometric third-generation hydrogen peroxide biosensor based on immobilization of Hb on gold nanoparticles /cysteine/ poly (p- aminobenzene sulfonic acid)-modified platinum disk electrode”, Colloids and Surfaces A:  2007, 295, 223-227. 　　24. F. X. Gao, R. Yuan*, Y. Q. Chai, S. H. Chen, S. R. Cao, M. Y.Tang , “Amperometric Hydrogen Peroxide Biosensor Based on the Immobilization of HRP on nano-Au/Thi /Poly (p-Aminobenzene Sulfonic Acid)-Modified Glassy Carbon Electrode”， Journal of Biochemical and Biophysical Methods，2007, 70(3), 407-413. 　　25. G. R. Ye, Y. Q. Chai, R. Yuan, L. Zhou, Y. Li, L. N. Zhang, “Salicylate Ion-Selective Electrode Based on New Tetranuclear Copper Complexes of O-Vannlin-methionine as Neutral Carriers”,Analytical Sciences, 2007, 23(2), 171-176. 　　26. D. P. Tang, R. Yuan*, Y. Q. Chai, “Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultaneous Multiple Immunoassays,” Clinical Chemistry,2007, 53(7), 1323–1329. 　　27. X. H. He, R. Yuan*, Y. Q. Chai, Y. Zhang, Y. T. Shi, “A new antibody immobilization strategy based on electrodeposition of gold nanoparticle and prussian blue for label-free amperometric immunosensor”, Biotechnology Letters, 2007, (1), 149-155. 　　28. Z. Q Tong, R. Yuan*, Y. Q. Chai, S. H. Chen, Y. Xie, “Direct electrochemistry of horseradish peroxidase immobilized on DNA/electro-deposited zirconium dioxide modified, gold disk electrode”, Biotechnology Letter, 2007, 29,791-795. 　　29. E. P. Luo, Y. Q. Chai, R. Yuan*, “Unsymmetrical tetradentate Schiff bases copper(II) complex as neutral carrier for thiocyanate-selective electrode”, Analytical Letters, 2007, 40, 369-386. 　　30. S. R. Cao, R. Yuan*, Y. Q. Chai, L. Y. Zhang, X. L. Li, F. X.Gao, “A mediator-free amperometric hydrogen peroxide biosensor based on HRP immobilized on a nano- Au/ poly 2,6-pyridinediamine- coated electrode”, Bioprocess and biosystems engineering, 2007, 30, 71-78. 　　31. F. C. Wang, R. Yuan*, Y. Q. Chai, “A new amperometric biosensor for hydrogen peroxide determination based on HRP-Nanogold-PTH-Nanogold-modified carbon paste electrode” , European food research and technology, 2007, 225(1), 95-104. 　　32. L. H. Gan, R. Yuan, “Influence of Cluster Size on the Structures and Stability of Trimetallic Nitride Fullerenes M3N@C80”, Chemphyschem, 2006, 7, 1306-1310. 　　33. D. P. Tang, R. Yuan*, Y. Q. Chai, “Electro-Transfer mediator microbiosensor Fabrication Based on Immobilizing HRP-Labeled Au Colloide on Gold Electrode Surface by 11-Mercaptoundecanoic noic Acid Monolayer”, Electroanalysis, 2006, 18(3) , 259-266. 　　34. S. H. Chen, R. Yuan*, Y. Q. Chai, L. Xu , N. Wang, X. L Li, L. Y. Zhang, “Amperometric hydrogen peroxide biosensor based on the immobilization of horseradish peroxidase (HRP) on the layer-by-layer assembly films of gold colloidal nanoparticles and toluidine blue”, Electroanalysis, 2006, 18(5) , 471-477. 　　35. Y. Zhuo, R. Yuan*, Y. Q. Chai, Y. Zhang, X. L. Li, N. Wang, Q. Zhu, “Amperometric enzyme immunosensors based on layer-by-layer assembly of gold nanoparticles and thionine on Nafion modified electrode surface for α-1-fetoprotein determinations”, Sensors and Actuators B, 2006, 114, 631-639. 　　36. Y. Liu, R. Yuan*, Y. Q. Chai, D. P.  Tang, J. Y. Dai , X. Zhong, “Direct electrochemistry of horseradish peroxidase immobilized on gold colloid/cysteine/nafion-modified platinum disk electrode” ,Sensors and Actuators B: Chemical,2006, 115, 109-115. 　　37. Q. Zhu, R. Yuan*, Y. Q. Chai, N. Wang, Y. Zhuo, Y. Zhang, X. L. Li, “A new potentiometric immunosensor for determination of α-fetoprotein based on improved gelatin–silver complex film”, Electrochimica Acta,2006, 51( 18), 3763-3768. 　　38. X. L. Li, R. Yuan*, Y. Q. Chai, L. Y. Zhang, Y. Zhuo，Y. Zhang, “Amperometric immunosensor based on toluidine blue/nano-Au through electrostatic interaction for determination of carcinoembryonic antigen”, Journal of Biotechnology, 2006, 123(3) 356-366. 　　39. S. R. Cao, R. Yuan, Y. Q. Chai, L. Y. Zhang,  X. L. Li,R. Chai,“Electrocatalytic Oxidation of Ascorbic Acid on 2,6-pyridinediamine / nano-Au / poly 2,6-pyridinediamine Modified Glassy Carbon Electrode and Its Analytical Application” Journal of the electrochemical society, 2006, 153(12), H223-H227. 　　40. Y. Z. Fu, R. Yuan, Y. Q. Chai, Y. Zhang, Y. G. Peng, “Electrochemical Immunoanalysis for Carcinoembryonic Antigen Based on Multilayer Architectures of Gold Nanoparticles and Polycation Biomimetic Interface on Glassy Carbon Eletrode”, Electroanalysis, 2006, 18(24), 2451-2457. 　　41. W. J. Xu, Y. Q. Chai, R.Yuan*. S. L. Liu “A novel thiocyanate-selective electrode based on a Zinc- phthalcyanine complex”, Analytical and Bioanalytical Chemistry，2006, 385: 926-936. 　　42. F. C. Wang, R. Yuan, Y. Q. Chai, “Direct electrochemical immunoassay based on a silica nanoparticles/sol–gel composite architecture for encapsulation of immunoconjugate”, Applied Microbiology and Biotechnology, 2006, 72(4), 671-675. 　　43. L. Y. Zhang, R. Yuan*, Y. Q. Chai, S. H. Chen, N. Wang, Q. Zhu,“Layer-by-layer self-assembly of films of nano-Au and Co(bpy)33+ for the determination of Japanese B encephalitis vaccine” , Biochemical Engineering Journal, 2006, 28(3),231-236. 　　44. D. P. Tang, R. Yuan*, Y. Q. Chai, X. Zhong, Y. Liu, J. D. Dai “Electrochemical detection of hepatitis B surface antigen using colloidal gold nanoparticles modified by a sol-gel network interface”, Clinical Biochemistry, 2006, 39(3), 309-314. 　　45. D. P. Tang, R. Yuan*, Y. Q. Chai, “Direct electrochemical immunoassay based on immobilization of protein-magnetic nanoparticle composites on to magnetic electrode surfaces by sterically enhanced   magnetic field force”, Biotechnology Letters , 2006, 28(8), 559-565. 　　46. D. P. Tang, R. Yuan*, Y. Q. Chai, “Novel immunoassay for carcinoembryonic antigen based on protein A-conjugated immunosensor chip by surface plasmon resonance and cyclic voltammetry”, Bioprocess and Biosystem Engineering, 2006, 28, 315-321. 　　47. G. R. Ye, Y. Q. Chai, R. Yuan*, J. Y. Dai, “A mercury(II) ion–selective electrode based on N,N-dimethylformamide-salicylacylhydrazone as a neutral carrier”,Analytical Sciences, 2006, 22(4), 579-582. 　　48. D. P.  Tang, R. Yuan*, Y. Q. Chai, “ Ligand-Functionalized Core/Shell Ag@Au Nanoparticles Label-Free Amperometric Immun-Biosensor”, Biotechnology and Bioengineering, 2006, 94(5), 996-1004. 　　49. D. P. Tang, R. Yuan*, Y. Q. Chai, “. Electrochemical immunosensing strategies based on immobilization of anti-IgG on mixed self-assembly monolayers carrying surface amide or carboxyl groups”, Analytical Letters,2006, 39(9), 1809-1821. 　　50. Y. Z. Fu, R. Yuan*, Y. Q. Chai, L. Zhou, Y. Zhang, “Coupling of a Reagentless Electrochemical DNA Biosensor with Conducting Polymer Film and nanocomposite as Matrices for the Detection of the HIV DNA Sequences”, Analytical Letters, 2006, 39(3), 467 – 482. 　　51. Q. Zhu, R. Yuan*, Y. Q. Chai, Y. Zhuo, Y. Zhang, X. L. Li, N. Wang, “A Novel Amerometric Biosensor for Determination of Hydrogen Peroxide Based on Nafion and Polythionine as well as Gold Nanoparticles and Gelatin as Matrixes”, Analytical Letters, 2006, 39(3), 483 – 494. 　　52. W. J. Xu, Y. Q. Chai, R. Yuan, L. Xu, S. L. Lliu, “Highly Selective Iodide Electrode Based on the Copper(II)-N,N’-bis (salicylidene)-1,2-bis(p-aminophenoxy)-ethane Tetradentate Complex”, Analytical Sciences, 2006, 22, 1345-1349. 　　53. M. Y. Tang, R. Yuan, Y. Q. Chai, “A new amperometric biosensor based on HRP/nano-Au/L-Cysteine/ Poly (o-aminobenzoic acid)-membrane-modified platinum electrode for the determination of hydrogen peroxide”, Chinese Journal of Chemistry, 2006, 24, 1575-1580. 　　54. Y. Z. Fu, R. Yuan*, Y. Q. Chai, “Reagentless immunosensing assay via electrochemical impedance for hepatitis B surface antigen monitoring based on polypyrrole and gold nanoparticles as matrices”, Chinese Journal of Chemistry, 2006, 24, 59-64. 　　55 . A. L. Sun, Y. Q. Chai, R. Yuan, G. F. Gui, “AHighly Selective Salicylate Membrane Electrode Based on N, N’-(aminoethyl) ethylenediamide Bis–(2-salicylideneimine) Binuclear Copper(II) Complex as Neutral Carrier”, Chinese Journal of Chemistry, 2006, 24(7), 894-898. 　　56. N. Wang, R. Yuan,* Y. Q. Chai, D. P. Tang, Q. Zhu, X. L. Li, “Electrocatalytic oxidation of NADH based on self-assembled colloidal gold and Nafion matrixes and Co complex mediator”, Chinese Chemical Letters, 2006, 17(5), 683-686. 　　57. F. C. Wang, Y. Q. Chai, R. Yuan*, “A Novel Tetraiodocadmate (II) – PVC Membrane Electrode for the Potentiometric Determination of Cadmium (II)”, Chinese Chemical Letters, 2006, 17, 941-944. 　　58. D. P. Tang, R. Yuan* , Y. Q. Chai, L. Y. Zhang, X. Zhong, Y. Liu, J. Y. Dai, “Preparation and application on a kind of immobilization method of anti-diphtheria for potentiometric immunosensor modified colloidal Au and polyvinyl butyral as matrixes”, Sensors and Actuators B: Chemical, 2005, 104 ,199-206. 　　59．X. Zhong R. Yuan*, Y. Q. Chai, Y. Liu, J. Y. Dai and D. P. Tang “Glucose biosensor based on self-assembled gold nanoparticles and double-layer 2d-network 3-mercaptopropyl)- trimethoxysilane polymer onto gold substrate”，Sensors & Actuators: B. Chemical ，2005, 104 ,191-198 　　60．D. P. Tang, R. Yuan*, Y. Q. Chai, Y. Liu, J. Y. Dai, X. Zhong, “Novel potentiometric immunosensor for determination of diphtheria antigen based on compound nanoparticles and bilayer two-dimensional sol-gel as matrices”, Analytical and Bioanalytical Chemistry，2005, 381, 674-680. 　　61. R. Yuan*, Y. Liu, Q. F. Li, Y. Q. Chai, C. L. Mo, X. Zhong , D. P., Tang, J. Y. Dai, “Electrochemical characteristics of a platinum electrode modified with a matrix of polyvinyl butyral and colloidal Ag containing immobilized horseradish peroxidase” Analytical and Bioanalytical Chemistry，2005 , 381: 762-768. 　　62. L. Xu, R. Yuan*, Y. Q. Chai, X. L. Wang, “A Novel salicylate-selective electrode based on a Sn(IV) complex of salicylal-imino acid Schiff base”, Analytical and Bioanalytical Chemistry，2005, 381: 781–787. 　　63.L. Y. Zhang, R. Yuan*, X. Q. Huang, Y. Q. Chai, D. P. Tang, S. R. Cao, “A new label-free amperometric immunosenor for rubella vaccine”, Analytical and Bioanalytical Chemistry，2005 , 381(5), 1036-1040. 　　64. L. Xu, R. Yuan*,Y. Q. Chai, Y. Z. Fu，“Novel Membrane Potentiometric Thiocyanate Sensor Based on Tribenzyltin(IV) Dithiocarbamate”, Electroanalysis, 2005, 17(11), 1003-1007. 　　65. J. Y. Dai, Y. Q. Chai, R. Yuan*, Y. S. Zhang, Y. Liu, X. Zhang, D. P, Tang, “Thiocyanate-selective PVC membrane electrode based on tricoordinate Schiff base copper(II) complex”, Chemistry Letters, 2005, 34(1), 62-63. 　　66. L. Xu, R. Yuan*, Y. Q. Chai, “Mercury(II) ion Potentiometric Sensor Based on a Sulfur Schiff’s Base 1-(2-Hydroxy-1,2-diphenylethylidene)thiosemicarbazide as Ionophore” Chemistry Letters, 2005 , 34(3) , 440-441. 　　67. Q. Zhu, Y. Q. Chai, R. Yuan*, N. Wang , X. L. Li “Development of a Biosensor for the Detection of Carcinoembryonic Antigen Using Faradic Impedance Spectroscopy”, Chemistry Letters, 2005, 34(12), 1682-1684. 　　68. Y. Z.  Fu, R. Yuan*, L. Xu, Y. Q. Chai, Y. Liu, D. P. Tang, Y. Zhang. “Electrochemical impedance behavior of DNA biosensor based on colloidal Ag and bilayer two-dimensional sol-gel as matrices”, Journal of Biochemical and Biophysical Methods, 2005, 62(2), 163-174. 　　69. Y. Z. Fu, R. Yuan*，L. Xu, Y. Q. Chai, Y. Liu, X. Zhong, D. P. Tang, “Indicator free DNA Hybridization detection via EIS based on     self-assembled gold nanoparticles and bilayer two-dimensional 3-mercaptopropyltrimeth- oxysilane onto a gold substrate” ,Biochemical Engineering Journal, 2005, 23(1) , 37-44. 　　70. J. Y. Dai, Y. Q. Chai,  R. Yuan*, L. X. An, Y. Liu, X. Zhong, D. P. Tang, “Tricoordinate schiff base copper (II) complex as neutral carrier for highly selective thiocyanate electrode”, Analytical Letters, 2005, 38(3), 389-400. 　　71. L. Xu, R. Yuan*, Y. Z. Fu, Y. Q. Chai, “Potentiometric membrane electrode for salicylate based on an organotin complex with a salicylal Schiff base of amino acid”, Analytical Sciences, 2005, 21(3), 287-292. 　　72. X. Zhong, R. Yuan*, Y. Q. Chai, J. Y. Dai，Y. Liu，D. P. Tang， “An Amperometric biosensor for glucose based on self-assembling nanoparticles and electrosynthesis of poly-o-diaminobenzene on the Prussian blue modified gold electrode”, Analytical Letters， 2005 ,38(7)，1085-1097. 　　73. F. C. Wang， Y. Q. Chai, R. Yuan*, C. H. Chen, J. Y. Dai, L. Xu,“A Selective Membrane Electrode for Thiocyanate Ion Based on a Bis-taurine-salicylic Binuclear Copper(II) Complex as Ionophore”，Chinese Journal of Chemistry, 2005, 23(7), 865-869. 　　74. D. P. Tang, R. Yuan*, Y. Q. Chai, L. Y. Zhang, J. Y. Dai, Y. Liu, X. Zhong, “Potentiometric Immunosensor Based on Immobilization of Hepatitis B Surface Antibody on Platinum Electrode Modified Silver Colloids and Polyvinyl Butyral as Matrixes”, Electroanalysis, 2005, 17(2), 155-161. 　　75. L. Y. Zhang, R. Yuan*, Y. Q. Chai, X. L. Li, X. Zhong, “An amperometric immunosensor for rubella vaccine”, Analytical Letters, 2005, 38(10), 1549-1558. 　　76. J. Y. Dai, R. Yuan*, Y. Q. Chai, L. X. An, X. Zhong, Y. Liu, D. P. Tang, “Highly thiocyanate- selective pvc membrane electrode based on lipophilic ferrocene derivative”, Electroanalysis, 2005, 17(20), 1865-1869. 　　77. Y. Q. Chai, J. Y. Dai, R. Yuan*, X. Zhong. Y. Liu, D. P. Tang, “Highly thiocyanate-selective membrane electrodes based on the N,NN-bis-(benzaldehyde)-glycine copper(II) complex as a neutral carrier”, Desalination, 2005, 180, 207-215 　　78. Y. Z. Fu, R. Yuan*, D. P. Tang, Y. Q. Chai, “Study on the immobilization of anti-IgG on Au-colloid modified gold electrode via potentiometric immunosensor, cyclic voltammetry, and electrochemical impedance techniques”, Colloids and Surfaces B: , 2005, 40(1), 61-66. 　　79．Y. Q. Chai, R. Yuan*, J. Y. Dai , L. Xu, A. L. Sun, G. F. Gui, “Highly salicylate-selective membrane electrode based on  N,N’-bis-(furaldehyde)-glycinecopper(II) complex as neutral carrier”, Analytical Letters, 2005, 38(1), 45-56 　　80. Y. Liu, R. Yuan*, Q. F. Li, Y. Q. Chai, X. Zhong, D. P. Tang,  J. Y. Dai, “A New Biosensor for Hydrogen Peroxide Based on Ag Colloid-modified Electrode and Azure C Mediation”, S. Afr. J. Chem., 2005, 58, 4–8. 　　81. D.P. Tang, R. Yuan, Y.Q. Chai, X. Zhong, Y. Liu, J.Y. Dai, L.Y. Zhang，“Novel potentiometric immunosensor for hepatitis B surface antigen using a gold nanoparticle-based biomolecular immobilization method”  Analytical Biochemistry, 2004, 333(2), 345-350. 　　82．D. P. Tang, R. Yuan,Y. Q. Chai, J. Y. Dai, X. Zhong, Y. Liu, “A novel immunosensor based on immobilization of hepatitis B surface antibody on platinum electrode modified colloidal gold and polyvinyl butyral as matrices via electrochemical impedance spectroscopy”, Bioeletrochemistry, 2004, 65(1),15-22. 　　83．Y. Q. Chai, R. Yuan, L. Xu, W. J. Xu, J. Y. Dai and F. Jiang, “A Highly sensitive PVC membrane iodide electrode based on the complexes of mercury(II) as neutral carrier”, Analytical and Bioanalytical Chemistry，2004 , 380(2), 333-338. 　　84．Z. Y. Sun, R. Yuan, Y. Q. Chai, L. Xu, , X. X. Gan, W. J. Xu，“Study of a bis-furaladehyde Schiff base copper(II) complex as carrier for preparation of highly selective thiocyanate electrodes”，Analytical and Bioanalytical Chemistry，2004, 378, 490~494. 　　85. D.P. Tang, R. Yuan, Y.Q. Chai, L. Y. Zhang, X. Zhong, J. Y. Dai, Y. Liu, “Novel potentiometry immunoassay with amplified sensitivity for diphtheria antigen based on nafion, colloidal Ag and polyvinyl butyral as matrixes”, Journal of Biochemical and Biophysical Methodes, 2004, 61,299-311. 　　86．D.P. Tang, R. Yuan, Y.Q. Chai, X. Zhong, Y. Liu, J. Y. Dai, “Novel potentiometry immunoassay for the detection of diphtheria antigen based on colloidal gold and polyvinyl butyral as matrixes”, Biochemical Engieering Journal, 2004, 22, 43-49. 　　87．X. Q. Huang, Y. Q.Chai, R. Yuan, X. L. Wang, Q. F. Li, “Highly selective thiocyanate electrode based on bis-[N-(2-hydroxyethyl)salicylaldimino]copper(II) complex as a neutral carrier”, Analytical Sciences, 2004, 20(8),1185-1188. 　　88. J. Y. Dai, Y. Q. Chai, R. Yuan, X. Zhong, Y. Liu, D. P. Tang, “Bis-dimethylaminobenzaldehyde Schiff-base Cobalt(II) Complex as a Neutral Carrier for a Highly Selective Iodide Electrode”, Analytical Sciences, 2004, 20(12), 1661- 1666. 　　89. 周路，叶光荣，袁若*，柴雅琴，陈素明，“甲磺酸帕珠沙星分子印迹手性电容型传感器”，中国科学，B辑：2007, 37(1), 48-53. 　　90. 袁若*，曹淑瑞，柴雅琴，高凤仙，赵青，唐明宇，童忠强，谢轶，“血红蛋白/带正电的纳米金层层自组装膜修饰电极的制备及其电催化性能的研究”，中国科学，B辑： 2007, 37(2), 170-177. 　　91. 张丽娜，柴雅琴，袁若*，李艳，叶光荣，“基于2,3-丁二酮双缩氨基硫脲为中性载体的新型银离子选择性电极的研究”化学学报，2007, 65(6), 537-541. 　　92. 袁若*, 卓颖, 柴雅琴, 张英, 孙爱丽，“基于纳米金/硫堇层层自组装的新型电流型酶-癌胚抗原免疫传感器”，中国科学 B(辑)，2006, 36(5), 425-432. 　　93. 袁若*，唐点平，柴雅琴，张凌燕，刘颜，钟霞，戴建远，“高灵敏电位型免疫传感器对乙型肝炎表面抗原的诊断技术研究”，中国科学 (B 辑), 2004, 34(4), 279-286. 　　94. 黎雪莲, 袁若*, 柴雅琴, 朱强, 张凌燕, 王娜，“基于多层酶/纳米金固定甲胎蛋白免疫传感器的研究”，化学学报，2006, 64(4), 325-330. 　　95. 张凌燕，袁若*，柴雅琴，曹淑瑞，黎雪莲，王娜，“基于辣根过氧化物酶 / 纳米金 / 辣根过氧化物酶 /多壁纳米碳管修饰的过氧化氢传感器的研究”，化学学报，2006, 64(16),1711-1715. 　　96. 归国风, 柴雅琴, 袁若*，孙爱丽，王福昌，“新型双核铜金属配合物为中性载体的硫氰酸根离子高选择性电极的研究”，化学学报，2006, 64(21),2185-2189. 　　97．唐点平，袁若*，柴雅琴，刘颜，钟霞，戴建远，“纳米金修饰玻碳电极固载抗体电位型白喉类毒素免疫传感器的研究”化学学报，2004, 62(20): 2062-2066. 　　98．王秀玲，袁若*，徐岚，柴雅琴，孙志勇，黄晓靖，李群芳，赵勤，“双安息香缩三乙四胺双核钴硫氰酸根的离子电极研究”，高等学校化学学报，2004, 25(4), 633-635.

承担项目

1994年以来，袁若作为项目负责人主持并完成了国家自然科学基金、科技部科技型中小企业创新基金、教育部优秀青年教师资助计划基金、国家教育部留学生基金、重庆市科委攻关基金、重庆市自然科学基金等12项课题，并参加了日本文部省重点基金、香港RGC基金、国家自然科学重点基金、中国科学院长春应用化学研究所电化学开放实验室基金课题、国家教委博士点基金等6项课题的研究。 　　主持的科研项目 　　1. 国家自然基金项目：三维网状超分子纳米水胶及金属纳米微粒固载抗体蛋白的高灵敏电化学免疫传感器研究（2007-2009） 　　2. 重庆市自然科学基金：高灵敏纳米金修饰白喉免疫生物传感器研究(2004.8~2007.8) 　　3. 科技部科技型中小企业技术创新基金: 高分子膜pH传感器(2003.8~2005.8) 　　4. 重庆市自然科学基金：酶催化高立体选择性手性物电化学合成及其传感器研究（2002.8~2005.8） 　　5. 教育部优秀青年教师资助计划项目：单酶催化高立体选择性手性醇电化学合成及其传感器研究（2002.1~2005.1） 　　6. 重庆市科委攻关项目：新型非玻璃膜固态pH传感器研制（2000.6~2003.6） 　　7. 湖南省自然基金：高选择性醇脱氢酶催化光学活性物电化学还原及生物传感器研究（1999~2000） 　　8. 国家自然科学基金：单酶催化高选择性羰基手性物电化学还原及其传感器研究（1998~2000） 　　9. 教育部留学生基金：酶催化电化学还原及其生物传感器研究（1997~1999） 　　10. 湖南省自然基金：新型金属配合物中性载体阳离子选择电极研究（1995~1996）