姓名：范明性别：男职称：研究员、教授招生院所：基础医学院招生类型：科学学位(博)科学学位(硕)招生专业：神经生物学(博)神经生物学(硕)研究方向名称：低氧等环境因素对神经肌肉发育与损伤修复的作用与机制电子信箱：fanmingchina@126.com

社会任职

1.全国应用生理专业委员会主任委员

2.亚太地区高原医学会常务理事

3.中国神经科学会常务理事

个人简历

1.197610-198007:北京第二医学院医疗四系学生

2.198009-198307:军事医学科学院硕士

3.198509-198807:军事医学科学院博士

4.1989-1993:军事医学科学院基础医学研究所副研究员

5.1993-:军事医学科学院基础医学研究所研究员

6.2006-:首都医科大学客座教授

重要学术论文

1.DingXF,ZhaoYQ,FanWH,WuLY,HuangX,WangF,HeYL,LiuSH,WuY,ZhaoT,WuY,ZhuLL,FanM..Genetransferintothebothsidesofpostnatalcerebralcortexusingtweezerelectrode.CNSNeurosciTher..2013,19(3):197-8..SCI

2.WangY,YangJ,LiH,WangX,ZhuL,FanM,WangX..HypoxiapromotesdopaminergicdifferentiationofmesenchymalstemcellsandshowsbenefitsfortransplantationinaratmodelofParkinson'sdisease..PLoSOne..2013,8(1):e54296.SCI

3.XiongL,WangF,HuangX,LiuZH,ZhaoT,WuLY,WuK,DingX,LiuS,WuY,ZhaoY,ZhuLL,FanM.DNAdemethylationregulatestheexpressionofmiR-210inneuralprogenitorcellssubjectedtohypoxia.FEBSJ..2012,279(23):4318-26.SCI

4.DingXF,ZhaoYQ,HuZY,LinK,WangF,LiuSH,WuY,WuLY,ZhaoT,HuangX,WuY,ZhuLL,FanWH,FanM.Efficientgenetransferintoneonatalmousebrainusingelectroporation.NeurochemRes..2012,37(7):1392-8..SCI

5.1.XinHuang,JiaSun,TongZhao,KuiwuWu,KazutadaWatanabe,Zhi-ChengXiao,LinglingZhu,MingFan.LossofNB-3aggravatescerebralischemiabyimpairingneuronsurvivalandneuritegrowth..Stroke.2012,42:2910-2916.SCI

6.2.XiangLi,XuWang,PengZhang,LinglingZhu,TongZhao,ShuhongLiu,YanWu,XiaopingChen,MingFan..Extracellularsignal-regulatedkinase1/2mitogen-activatedproteinkinasepathwayisinvolvedininhibitionofmyogenicdifferentiationofmyoblastsbyhypoxia.ExpPhysiol,.2011,061382:1-8.SCI

7.ZhuLL,ZhaoT,huangX,FanM.Geneexpressionprofilesandmetabolicchangesinembryonicneuralprogenitorcellsunderlowoxygen..CellReprogram..2011,13(2)::113-20..SCI

8.5.XinHuang,Ling-lingZhua,TongZhao,Li-yingWu,Kui-wuWu,MelittaSchachner,Zhi-ChengXiao,MingFan..CHL1negativelyregulatestheproliferationandneuronaldifferentiationofneuralprogenitorcellsthroughactivationoftheERK1/2MAPKpathway..MolecularandCellularNeuroscience.2011,;46::296–307..SCI

9.7.Jun-XiaZheng,YangZheng,HuiZhi,YiDai,Nai-LiWang,Yan-XiongFang,Zhi-YunDu,KunZhang,Ming-MingLi,Li-YingWu,MingFan..New3′,8′′-LinkedBiflavonoidsfromSelaginellauncinataDisplayingProtectiveEffectagainstAnoxia.Molecules.2011,16,:6206-6214.SCI

10.LiMM,WuLY,ZhaoT,XiongL,HuangX,LiuZH,FanXL,XiaoCR,GaoY,MaYB,ChenJJ,ZhuLL,FanM.Theprotectiveroleof5-HMFagainsthypoxicinjury.CellStressChaperones.2011,16(3)::267-73.SCI

11.3.WuLY,MaZM,FanXL,ZhaoT,LiuZH,HuangX,LiMM,XiongL,ZhangK,ZhuLL,FanM.Theanti-necrosisroleofhypoxicpreconditioningafteracuteanoxiaismediatedbyaldosereductaseandsorbitolpathwayinPC12cells.CellStressChaperones.2010,15(4)::387-94.SCI

12.2.ShiCG,WangLM,WuY,WangP,GanZJ,LinK,JiangLX,XuZQ,FanM..Intranasaladministrationofnervegrowthfactorproducesantidepressant-likeeffectsinanimals.NeurochemRes.2010,35(9)::1302-14.SCI

13.1.ZhaoYQ,GaoJT,LiuSH,WuY,LinMT,FanM.Geranylgeranylacetonepreconditioningmayattenuateheat-inducedinflammationandmultiorgandysfunctioninrats.JPharmPharmacol.2010,62(1)::99-105.SCI

14.5.LiuS,TianZ,YinF,ZhaoQ,FanM.Generationofdopaminergicneuronsfromhumanfetalmesencephalicprogenitorsafterco-culturewithstriatal-conditionedmediaandexposuretoloweredoxygen..BrainResBull..2009,80(1-2)::62-8.SCI

15.CancerInvest.ExpressionandfunctionalrolesofSmad1andBMPR-IBingliomadevelopment.CancerInvest.2009,27(7)::734-40.SCI

16.LeiXiong,TongZhao,XinHuang,Ling-lingZhu*,MingFan*..Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressandChaperones.2009,14:183-192.SCI

17.kuanzhang,TongZhao,XinHuang,Ling-lingZhu,MingFan..PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain..CellStressandChaperones.2009,【未填写卷（期）】:【未填写起止页码】.SCI

18.WuHT,FanJ,ZhuLL,FanM.Sema4CExpressioninNeuralStem/ProgenitorCellsandinAdultNeurogenesisInducedbyCerebralIschemia..Jmolneurosci.2009,【未填写卷（期）】:【未填写起止页码】.SCI

19.ZhangL,ZhengSS,WuHT,WuY,LiuSH,Fan,M,Zhang,J*.IdentificationofBLyS(BLymphocyteStimulator),aNon-Myelin-AssociatedProtein,asaFunctionalLigandforNogo-66Receptor..TheJournalofNeuroscience.2009,29(19):6348–6352.SCI

20.11.JingXT,WuHT,WuY,MaX,LiuSH,WuYR,DingXF,PengXZ,QiangBQ,YuanJG,FanWH,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells.CellMolNeurobiol..2009,29(1)::55-67.SCI

21.10.ZhangK,ZhaoT,HuangX,LiuZH,XiongL,LiMM,WuLY,ZhaoYQ,ZhuLL,FanM.PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain.CellStressChaperones.2009,14(4)::407-15.SCI

22.9.XiongL,ZhaoT,HuangX,LiuZH,ZhaoH,LiMM,WuLY,ShuHB,ZhuLL,FanM.Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressChaperones.2009,14(2)::183-92.SCI

23.8.WuH,FanJ,ZhuL,LiuS,WuY,ZhaoT,WuY,DingX,FanW,FanM.Sema4Cexpressioninneuralstem/progenitorcellsandinadultneurogenesisinducedbycerebralischemia.JMolNeurosci.2009,39(1-2)::27-39.SCI

24.6.GaoJT,LiuSH,YanYE,WuY,WuHT,XingC,GeXM,WangH,ZhaoYQ,FanM.Quinacrineprotectsneuronalcellsagainstheat-inducedinjury..CellBiolInt.2009,33(8)::874-81.SCI

25.YuS，ZhaoT，Fanming.Hypoxicpreconditioningup-regulatesglucosetransportactivityandglucosetransporter(GLUT1andGLUT3)geneexpressionafteracuteanoxicexposureintheculturedrathippocampalneuronsandastrocytes..Brainresearch.2008,23:22-9.SCI

26.WuLY,WangY,FanM.TheroleofhypoxiainthedifferentiationofP19embryonalcarcinomacellsintodopaminergicneurons..NeurochemRes.2008,33:2118-2125.SCI

27.DingX，FanW，FanM.LocalizationandcellulardistributionofCPNE5inembryonicmousebrain..Brainresearch.2008,11:20-8.SCI

28.TangYY,MaYH,FanYX,FengHB,WangJH,FengSG,LuQL,HuB,LinY,LiJ,ZhangY,WangY,ZhouL,FanM*.Centralandautonomicnervoussysteminteractionisalteredbyshort-termmeditation..ProcNatlAcadSciUSA.2008,105:5609-5613.SCI

29.QiangSun1,YanZhang1,GuangYang2,XiaopingChen3,YingaiZhang1,GuojunCao2,.Transforminggrowthfactor-b-regulatedmiR-24promotesskeletalmuscledifferentiation.NucleicAcidsResearchNucleicAcidsResearch.2008,【未填写卷（期）】:1-10.SCI

30.XuanWang,HaitaoWu,ZhenxingZhang,ShuhongLiu,JianYang,XiaopingChen,MingFan,XiaominWang..EffectsofInterleukin-6,LeukemiaInhibitoryFactor,andCiliaryNeurotrophicFactorontheProliferationandDifferentiationofAdultHumanMyoblasts..CellMolNeurobiol.2008,28:113–124.SCI

31.Yi-YuanTang,YinghuaMa,JunhongWang,YaxinFan,ShigangFeng,QilinLu,QingbaoYu,DanniSui,MaryK.Rothbart,MingFanandMichaelI..PosnerShort-termmeditationtrainingimprovesattentionandself-regulation.PNAS.2008,104:4317152–17156.SCI

32.ZhaoT,Zhangcui-ping,LinglingZhu,FanMing.Hypoxia-drivenproliferationofembryonicneuralstem/progenitorcells--roleofhypoxia-inducibletranscriptionfactor-1alpha..FEBSJ.2008,275(8):1824-34.SCI

33.HaitaoWu,XuanWang,ShuhongLiu,WenhongFan*,MingFan*.Sema4Cparticipatesinthemyogenicdifferentiationinvivoandinvitrothroughp38MAPKpathway..Eur.J.CellBiol..2007,86:331-344.SCI

34.PengZhang,XiaopingChen,MingFan.Signalingmechanismsinvolvedindisusemuscleatrophy.MedHypotheses.2007,69:310–321..SCI

35.【未填作者】.Pathophysiologicalfactorsunderlyingheatstroke.MedHypotheses.2006,22(2):118-123.SCI

36.【未填作者】.Dedifferentiationofadulthumanmyoblastsinducedbyciliaryneurotrophicfactorinvitro..MolBiolCell..2005,16(7):3140-51.SCI

37.【未填作者】.Neurogenesisintheadultratbrainafterintermittenthypoxia..BrainRes..2005,1055(1-2):1-6.SCI

38.LinglingZhu,LiyingWuandMingFan..Effectsofhypoxiaonproliferationanddifferentiationofneuralstemcells.MolNeurobiology.2005,31(1-3):231-242.SCI

39.JingXT,WuHT,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells..cellmolneurobiol.2002,29:55-67.SCI

主编或副主编的著作/译著

1.《神经科学进展（第三册）》,主编,高等教育出版社,2004

2.《神经科学进展（第二册）》,主编,高等教育出版社,2003

3.《特殊环境生理学》,副主编,军事医学出版社,2003

4.《蛋白质技术手册》,主编,科学出版社,2000

重要奖项

1.适度低氧促进脑损伤修复的途径与应用方案军队科技进步二等奖201211

2.NGF临床研究北京市科技进步奖三等2008

3.兴奋毒性脑损害干预研究辽宁省科技进步一等奖2004

4.神经营养因子的系列研究北京市科技进步二等奖2003

5.海马神经元缺氧损伤机制及保护措施的研究军队科技进步二等奖1999

6.人脑源性神经营养因子基因工程及其生物学作用的研究军队科技进步二等奖1998

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