现主要从事药理活性复杂天然产物及药物先导化合物结构修饰、构效关系、半合成以及不对称全合成研究，包括：
　　1．中药抗肿瘤活性成分雷公藤乙素的不对称全合成研究；
　　2．中药抗肿瘤活性成分异呋喃二烯的结构修饰、衍生物全合成与构效关系研究；
　　3．丹参素、丹酚酸A和丹酚酸B的不对称全合成研究；
　　4．药物分子合成相关新化学反应方法的研究。
　　5．国外最新原料药及相关中间体合成工艺仿制与改进研究。

　　发表论文十余篇，大部分被SCI收录。

　　1． 关玉昆，房丽晶，唐志勇，李裕林． “3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成”,高等学校化学学报, 2007,28(7),1307-1309． （SCI）

2． Yu-Kun．Guan,Yu-Lin．Li．"The First Preparation of Enantiopure 1-Methyl-7- oxabicyclo[2．2．1]heptan-2-one, a Versatile Chiral Building Block for Terpenoids", Chirality, 2005,17(2),113-118． （SCI）
　　3． 关玉昆，房丽晶，郑国君，李裕林．"对映体纯1-甲基-7-氧杂双环[2．2．1]庚烷-2-酮的首次制备",高等学校化学学报,2005,26(2),264-266． (SCI )
　　4． 关玉昆，李平，周罡，高晓蕾，李裕林．"5 ,11-二羟基-2-氧代桉烷-3-烯的全合成",高等学校化学学报,2005,26(7),1281-1283． (SCI )
　　5． Yu-Kun．Guan,Ping．Li,Li-Jin．Fang,Yu-Lin．Li．"The First Total Synthesis of 3-oxo-11,12,13-trihydroxyeudesm-4-ene",Chinese Chemical Lett．, 2005, 16(6), 711-712． (SCI-E )
　　6． 关玉昆，李平，唐志勇，张晨曦，李裕林． "新型的芳杂环烷基化生成3'-氧官能团取代侧链反应",有机化学,2004,24(suppl．),169． (SCI-E )
　　7． 关玉昆，李平，陈锦春，郑国君，李裕林． "methyl-5-hydroxy-4-oxo-11(13)- dehydroiphionoate的立体选择性全合成"，有机化学,2003,23(suppl．),455． (SCI-E )

     4

5 

ZL200610040277.2

校级

 
　　论  文：
　　发表论文8篇，其中被SCI、ISTP收录的期刊论文及会议论文共5 篇。
　　1．毕毅，徐进宜，吴晓明*。抗艾滋病药物的研究进展，中国现代应用药学杂志，2005，22（6），461-465
　　2．毕毅，徐进宜，吴晓明*。白桦酸类化合物的研究进展，中国新药杂志，2005，14（1），23-26
　　3．Yi Bi, Jinyi Xu, Xiaoming Wu* et al. Synthesis and Cytotoxic activity of 17-Carboxylic Acid Modified 23-Hydroxy Betulinic Acid Ester Derivatives. Bioorganic & Medicinal Chemistry Letters, 2007，17（5），1475-1478。(SCI, IF=2.5)
　　4．毕毅，徐进宜，吴晓明* 等。23-羟基白桦酸的30位羟基衍生物的合成及抗肿瘤活性研究，中国药科大学学报，2007，38 (2), 108-111
　　5. Jin Yi Xu, Yi Zeng, Qian Ran, Zhen Wei,Yi Bi, Xiaoming Wu* et al. Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 2007, 17 (10), 2921-2926。(Revised, Accepted. SCI, IF=2.5)
　　6. Peiqing Zhu, Yi Bi, Jinyi Xu, Zan Li, Jun Liu, Luyong Zhang, Wencai Ye, Xiaoming Wu. Terpenoids. III: Synthesis and biological evaluation of 23-hydroxy betulinic acid derivatives as novel inhibitors of glycogen phosphorylase. Bioorganic & Medicinal Chemistry Letters, 2009, 19(24):6966–6969。(Revised, Accepted. SCI, IF=2.5)
　　7．Tian Wang, Qingguo Meng*, Jiangfeng Zhang, Yi Bi, Naicai Jiang. Study on the myocardial injury induced by isoproterenol. Fitoterapia. 2010. (Revised, Accepted. SCI, IF=1.2).
　　8．Bing Hana, Qingguo Menga,*, Qiang Lib, Jiangfeng Zhanga, Yi Bia, Naicai Jianga. The effect of 20(S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol.. 2010 。(Revised, Accepted, SCI, IF=0.713).

环孢素脂质体滴眼液的研制与应用

胸腺五肽多囊脂质体的制备及药代动力学研究

2009年山东省高等学校优秀科研成果奖

2009年烟台大学优秀科研成果奖

   [1]赵烽, 姜永涛, 戴胜军, 刘珂. 天然药物化学的实践教学改革. 中国中医药现代远程教育, 2010, 8(1): 62-64.
　　   [2]Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J Ethnopharmacol, 2009, 122(3): 457-462.（SCI: 2.26）
　　   [3]Liu H, Zhao F, Yang R, Wang M, Zheng M, Zhao Y, Zhang X, Qiu F, Wang H. Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia. Phytochemistry, 2009, 70(6): 773-778.（SCI: 2.946）
　　   [4]Zhou K, Zhao F, Liu Z, Zhuang Y, Chen L, Qiu F. Triterpenoids and flavonoids from celery (Apium graveolens). J Nat Prod, 2009, 72(9): 1563-1567.（SCI: 2.843）
　　   [5]Lou Y, Zhao F, Wu Z, Peng K, Wei X, Chen L, Qiu F. Germacrane-type sesquiterpenes from Curcuma wenyujin. Helv Chim Acta, 2009, 92: 1665-1672.（SCI: 1.396）
　　   [6]Lou Y, Zhao F, He H, Peng K, Zhou X, Chen L, Qiu F. Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric oxide production. J Asian Nat Prod Res, Aug 18, 2009
　　   [7]Gao H, Zhao F, Chen GD, Chen SD, Yu Y, Yao ZH, Lau BW, Wang Z, Li J, Yao XS. Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation. Phytochemistry, 2009, 70(6): 795-806.（SCI: 2.946）
　　   [8]Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F, Yuan CS. Potential anti-cancer activities of furanodiene, a sesquiterpene from Curcuma wenyujin. Am J Chin Med, 2009, 37(3): 589-596. (SCI:)
　　   [9]赵凯华，赵烽，刘珂. 腺梗豨莶提取物对脂多糖活化巨噬细胞释放一氧化氮的抑制作用. 烟台大学学报(自然科学与工程版), 2009, 22(2): 137-140.
　　[10]王家强, 刘军峰, 关玉昆, 赵烽, 许卉, 刘珂. 雷公藤红素衍生物的合成与评价. 中草药, 2009, 40(2): 201-204.
　　[11]伍旭, 赵烽, 刘珂. 冬凌草甲素衍生物的制备和评价. 中草药, 2009, 40(3): 348-352.
　　[12]Qiu L, Zhao F, Jiang ZH, Chen LX, Zhao Q, Liu HX, Yao XS, Qiu F. Steroids and Flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production. , 2008, 71(4): 642-646.（SCI: 2.267）
　　[13]Qiu L, Zhao F, Liu H, Chen L, Jiang Z, Liu H, Wang N, Yao X, Qiu F. Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L. var. franchetii, and their effect on NO release in macrophages. Chem Biodivers, 2008, 5(5): 758-763.（SCI: 1.659）
　　[14]Zhao F, He EQ, Wang L, Liu K. Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level. J Asian Nat Prod Res, 2008 (in press).（SCI: 1.065）
　　[15]Zhao F, Xu H, Wang L, Jiang YT, Liu K. Inhibitory effects of sesquiterpenes from Saussurea lappa on the overproduction of nitric oxide and TNF-α release in LPS-activated macrophages. J Asian Nat Prod Res, 2008, (in press).（SCI: 1.065）
　　[16]Sun J, Lou H, Dai S, Xu H, Zhao F, Liu K. Indole alkoloids from Nauclea officinalis with weak antimalarial activity. Phytochemistry, 2008, 69(6): 1405- 1410.（SCI: 2.946）
　　[17]Zhao F, Ohtsuki T, Yamada K, Yoshinari S, Kita K, Watanabe Y, Watanabe K. Isolation and physiochemical properties of protein-rich nematode mitochondrial ribosomes. Biochemistry, 2005, 44(25): 9232-9237.（SCI: 4.008）
　　[18]Zhao F, Watanabe Y, Nozawa H, Daikonnya A, Kondo K, Kitanaka S. Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus L.), J Nat Prod, 2005, 68(1): 43-49.（SCI: 2.267）
　　[19]Nozawa H, Nakao W, Zhao F, Kondo K. Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon. Mol Nutr Food Res, 2005, 49(8): 772-778.（SCI: 2.071）
　　[20]Zhao F, Nozawa H, Daikonnya A, Kondo K, Kitanaka S. Inhibitors of nitric oxide production from hops (Humulus lupulus L.), Biol Pharm Bull, 2003, 26(1): 61-65.（SCI: 1.317）
　　[21]Zhao F, Murota S, Morita I, Yao XS. Inhibitory effects of antioxidants on NF-κB activation in bovine carotid artery endothelial cells. Acta Biochim Biophys Sin, 2000, 32(4): 342-346. (SCI: 0.505)
　　[22]王潞, 赵烽, 刘珂. 牛蒡苷元诱导人白血病细胞凋亡的作用及机制. 药学学报, 2008, 43(5): 542-548.
　　[23]王潞, 赵烽, 许卉, 刘珂. 喜炎平注射液对巨噬细胞分泌炎性因子的影响. 中药药理与临床, 2008, 24(1): 36-39.
　　[24]王潞, 赵烽, 刘珂. 牛蒡子苷及牛蒡子苷元的药理作用研究进展. 中草药, 2008, 39(3): 467-470.
　　[25]王珊, 郑艳萍, 孙秀燕, 刘珂, 赵烽. 温莪术油对脂多糖活化巨噬细胞释放一氧化氮的抑制作用. 烟台大学学报(自然科学与工程版), 2008, 21(1): 71-74.
　　[26]郑艳萍，孙秀燕，巴真真，林东海，赵烽. 呋喃二烯的体内外抗肿瘤作用研究. 烟台大学学报(自然科学与工程版), 2008, 21(2): 361-365.
　　[27]王潞, 何恩其, 王珊, 赵烽, 许卉, 刘珂. 18种木香倍半萜对6种人源肿瘤细胞增殖的影响. 天然产物研究与开发, 2008 (in press).
　　[28]何恩其, 赵烽. 穿心莲的药理作用及研究进展. 中医药导报, 2007, 13(5): 107-108.
　　[29]赵烽, 室田诚逸, 森田育男, 姚新生. NF-κB与疾病. 生命科学, 2001,13(1): 10-13.
　　[30]赵烽, 张萌佳, 姚新生. 酸性染料比色法测定骆驼蓬种子总生物碱的含量. 中草药, 2000, 31(9): 660-662.
　　[31]Zhao F, Morita I, Murota S, Yao XS. Anti-inflammatory activities of extracts from Phyllanthus emblica and Betula alnoides through transcription factor NF-κB pathway. Journal of Traditional Medicines, 16: 155-162.

[1] Wenyan Wang, Ke Liu, Hongwei Dong and Wanhui Liu*. High-performance liquid chromatography spectrometric analysis of tripterin in rat plasma. J Chromatography B. 2008, 863, 163-166.
　　[2 ] Dafeng Chu, Wanhui Liu, Youxin Li, Pengfei Li, Jingkai Gu, Ke Liu. Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. Planta Medica. 2006, 72: 552-5.
　　[3] Dafeng Chu, Wanhui Liu, Zhuo Huang, Shengsheng Liu, Xueqi Fu, Ke Liu. Pharmacokinetics and excretion of hydroxysafflor yellow A, a potent neuroprotective agent from safflower, in rats and dogs. Planta Medica. 2006, 72: 418-23.
　　[4] Wan Hui LIU, J.L., Song, K. Liu, D.F. Chu, Y.X. Li.“Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer’s disease”. J Controlled release. 2005，107:417-427.
　　[5]王进军; 刘万卉; 韩光范; 沈荣, “3-位环庚烷(酰)基取代的焦脱镁叶绿酸-a甲酯的合成基”. ,
　　[6] Yingwu Wang, Dafeng Chu, Jingkai Gu, J. Paul Fawcett, Yi Wu, Wanhui Liu. Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma. J Chromatography B. 2004, 803: 375-8.
　　[7] Dafeng Chu, Jingkai Gu, Wanhui Liu, J. Paul Fawcett, QG Dong. Sensitive liquid chromatographic assay for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in beagle dog plasma. J Chromatography B. 2003, 795: 377-82.
　　[8] Dafeng Chu, Xueqi Fu, Wanhui Liu, Ke Liu, Youxin Li. Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs. International Journal of Pharmaceutics. 2006, 325: 116–123
　　[9] Wan Hui LIU, Ying WANG, Jiang Hing TANG, Guo Li SHENand Ru Qin YU.Optical Fiber Sensor for Tetracycline Antibiotics Based on Fluorescence Quenching of Covalently Immobilized Anthracene.Analyst, 1998, 123, 365
　　[10] Wan Hui LIU, Ying WANG, Jiang Hong TANG, Guo Li SHENand Ru Qin YU.An optical sensor for metronidazole based on the fluorescence quenching of a copolymer bound flavone derivative.Analytical Sci. 1998, 14(3), 547-551.
　　[11] Wan Hui LIU, Ying WANG, Jiang Hong TANG, Guo Li SHEN and Ru Qin YU.An optical fiber sensor for berberine based on immobilized 1,4-bis(naphth[2,1-d]oxazale-2-yl)benzene in a new copolymer.Talanta, 1998, 46(4), 679-688.
　　[12] Wan Hui LIU, Ying WANG, Weijun Jin, Guo Li SHEN and Ru Qin YU.Solvatochromogenic flavone dyes for the detection of water in acetone.Anal. Chim. Acta, 1999, 383(3), 299-307.
　　[13] Wan Hui LIU, Ying WANG, Jiang Hong TANG, Guo Li SHEN and Ru Qin YU.Optosensing hydrochloric acid based on the fluorescence quenching of a flavone copolymer.Fresenius J. Anal. Chem., 1998, 362(4), 387-390.
　　[14] 刘万卉，杨欣，宁富强，段菁华，沈国励，俞汝勤.基于共价固定化苯嵌蒽酮荧光猝灭的药根碱光化学传感器.《分析化学》2000,28(1), 17-21.
　　[15] 王文艳,刘珂,董宏伟,刘万卉(通讯作者)High-performance liquid chromatography spectrometric analysis of tripterin in rat plasma.Journal Chromatography B.2008,863:163-166
　　[16] 黄卓,沙春洁,周凤梅,刘万卉(通讯作者).液相色谱-质谱法测定Beagle犬血浆中利培酮及9-羟基利培酮的浓度.烟台大学学报.2008.4, 21(2):110-114
　　[17] 盖芸芸,沙春洁,刘万卉(通讯作者).液相色谱-串联质谱法测定血浆中丹参素浓度.烟台大学学报.2008.1,21(1):35-39